trulicity vs ozempic dosagetrulicity vs ozempic dosage

2023 SingleCare Administrators. Trulicity belongs to a class of Type 2 diabetes medications called GLP-1 receptor agonists. In general, Ozempic and Trulicity are very similar. AdventHealth Diabetes Institute. In the same study, Ozempic helped more people reach an A1C goal of less than 7%. Learn about side effects, dosage, and. 930 ratings on Drugs.com. In animal studies, Ozempic and Trulicity increased the risk of thyroid tumors. All rights reserved. The oral tablet is called Rybelsus. It is also a non-insulin injectable medication. Is the ketogenic diet right for autoimmune conditions? However, in the SUSTAIN 7 clinical trial that compared the two medications, Ozempic was found to be more effective than Trulicity. What is the cost of Ozempic and Trulicity? In some cases Talk to your doctor before using alcohol together with semaglutide. To learn more about using Ozempic or Trulicity for your condition, talk with your doctor. It is For more information about the mild side effects of these two drugs, see Ozempics medication guide and Trulicitys medication guide. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Ozempic is manufactured by Novo Nordisk and Trulicity is manufactured by Eli Lilly. vs Trulicity1.5 mg. Lingvay, I., et al. Non-US Health Care Professionals, please go towww.novonordiskpro.com. Consult your healthcare provider for guidance. Biosimilars are like generic drugs. But unlike generics, which are made for non-biologic drugs, biosimilars are made for biologic drugs. Is Ozempic a better treatment option than Trulicity or vice versa? Those given the starting doses of Ozempic showed more weight loss, losing an average of about 14 pounds compared to about 6 pounds with the 1.5 mg dose of Trulicity. Semaglutide and dulaglutide do work in similar ways, but they are not identical and you may respond to them differently. If pancreatitis is confirmed, the drug should not be restarted. Trulicity may be used to manage blood sugar levels in children ages 10 years and older who have type 2 diabetes. vs Trulicity0.75 mg. Since type 2 diabetes is chronic and progressive, I strive to be vigilant about A1C increases and keep this in mind when choosing reasonable goals for my individual patients.2, In the SUSTAIN 7 trial, we evaluated the percentage of patients achieving an A1C <7%, which the ADA recommends as a reasonable goal for most adults.1,2Approximately 3 out of 4 patients were able to achieve A1C <7% with Ozempic1 mg.1. Trulicity, like Mounjaro, is manufactured by US-based Eli Lilly & Co. See your doctor right away if you have symptoms of thyroid cancer while taking Ozempic or Trulicity. By stimulating the same receptors, they cause your body to release more insulin, less glucagon, and digest food slower. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Last medically reviewed on January 25, 2021, Jardiance and Farxiga are brand-name prescription drugs that treat type 2 diabetes. The maximum recommended dose of Ozempic is 2 mg weekly. We avoid using tertiary references. They also help lower your risk for heart attack, stroke, and death from heart disease. Let's discuss. Prescription only. 2023 Novo Nordisk All rights reserved. Thats because these drugs work in the same way, so if your blood sugar is still too high while taking one of them, its unlikely to improve with a switch to the other drug. The first indication is to improve glycemic control in adults with Type 2 diabetes (in conjunction with diet and exercise). Alcohol can cause low blood sugar, and Ozempic or Trulicity can cause low blood sugar as well. Trulicity and Ozempic can not be used to treat type 1 diabetes. Anderson JW, Kendall CW, Jenkins DJ. Nancyis not an actual patient. An Indirect Treatment Comparison of Semaglutide 2.0 mg vs Dulaglutide 3.0 mg and 4.5 mg Using Multilevel Network Meta-regression. | You also shouldnt take these drugs if you have a rare form of cancer called multiple endocrine neoplasia syndrome type 2. In addition, Trulicity may be prescribed for this use in adults with type 2 diabetes who dont have heart disease but are at risk for it. Individual results may vary. There are many ways to save on Ozempic. Ozempic and Trulicity are also prescribed to lower the risk of certain heart problems in adults with type 2 diabetes and heart disease. Trulicity is given as an injection under the skin (subcutaneous injection) using a self-injecting pen device. However, independent research that compared the two medications, found that Ozempic lowered blood glucose levels further than Trulicity. It alerts doctors and patients about drug effects that may be dangerous. abdominal (belly) pain or upset stomach. With superior glycemic control results vs Trulicity, Ozempicmay be an appropriate treatment option for my adult patients with type 2 diabetes. Examples of questions you may want to ask include: To learn more about Ozempic, see these articles: To learn more about Trulicity, see these articles: To get information on different conditions and tips for improving your health, subscribe to any of Healthlines newsletters. If your blood sugar isnt well controlled with one of these drugs, your doctor is more likely to recommend adding a different type of medication to your treatment schedule. Its important to note that Optum Perks coupons cannot be used with any insurance copays or benefits. For patients who are using Ozempic for type 2 diabetes and lowering the risk of heart attack or stroke, 0.25 milligrams (mg) is injected once a week for four weeks at first, then increased to 0.5 mg. Healthcare providers might increase the dose as needed, but it's vital to consult with them before making any change yourself. Ozempic and Trulicity both belong to the same class of medication hence, they both have similar common gastrointestinal side effects such as: In rare instances, Ozempic and Trulicity can cause more serious side effects, including: For medical advice about side effects, talk with your health care provider and also read the medication guide and instructions for use that comes with Ozempic. The sections below provide dosage information for the conditions both Ozempic and Trulicity treat or prevent, along with details on how each drug is given. Alcohol may affect blood View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions. Young children, teens, adults, and senior citizens may have different blood sugar goals. The common dose range for Trulicity is 0.75-4.5 milligrams weekly. Oral (Rybelsus) Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. Drug overview & main differences | Conditions treated | Efficacy | Insurance coverage and cost comparison | Side effects | Drug interactions | Warnings | FAQ. A balanced diet can help manage blood sugar levels with type 2 diabetes. So, if you have a severe gastrointestinal condition, Ozempic might be more suitable for you. more Prescription only Prescribed for Weight Loss (Obesity/Overweight). Pratley RE, Aroda VR, Lingvay I, et al, on behalf of the SUSTAIN 7 investigators. If after . Trulicity vs Ozempic Study Participants Receiving Weekly Doses of 0.75 mg Trulicity and 0.5 mg Ozempic Average Starting A1C for Trulicity Participants - 8.2 Percent 0.75 mg Dose/Weekly A1C Decreased By 1.1 Percent With One Dose of 0.75 mg of Trulicity On a Weekly Basis, 51 Percent of These Participants Reached Their Goal of An A1C Below 7 Percent See also: Trulicity side effects in more detail. This chart may not include all mild side effects of these drugs. Ozempic and Trulicity are in a drug class called GLP-1 agonists, or glucagon-like peptide agonists. Healthcare professionals are the most reliable and accurate source of drug information. Last medically reviewed on January 15, 2023. This section describes possible side effects these drugs may cause. There arent any foods in particular that you need to avoid while taking Ozempic or Trulicity. Both drugs have been found to be effective for these uses. Trulicity and Ozempic are more active when you have consumed food and are digesting it. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. American Diabetes Association. Compare the efficacy and cost of Ozempic vs. metformin for the treatment of Type 2 diabetes. It is known as a GLP-1 receptor agonist. Ozempic is not approved for use in children. Guidelines from the American Diabetes Association (ADA) recommend using a glucagon-like peptide-1 (GLP-1) agonist, such as Ozempic or Trulicity, in adults with type 2 diabetes who also have one of the following conditions: The ADA doesnt recommend any GLP-1 agonist over another. *P=0.002vs Trulicity 0.75 mg How Exercise Can Help Manage, and Reverse, Type 2 Diabetes, The Best Type 2 Diabetes Diet For You: 7 Things to Consider. Conducting a head-to-head trial like SUSTAIN 7 has the potential to affect treatment decisions for some of the millions of adults with type 2 diabetes. Ozempic's starting dosage is 0.25 mg weekly, and the maximum dosage is 1 mg weekly.. Your doctor will likely suggest waiting a week after your last dose of the old drug before starting treatment with the new drug. These include drugs where there is a small window between therapeutic effect and toxicity such as Coumadin (warfarin), Lanoxin (digoxin), and seizure medications. Ozempic and Trulicity are both in the drug class called GLP-1 receptor agonists. Trulicity and Ozempic are both GLP-1 receptor agonist medications used to treat type 2 diabetes mellitus. If additional glycemic control is needed after at least 4 weeks on the 0.5 mg dose, the dosage may be increased to 1 mg once weekly. Dulaglutide (Trulicity) Dosage forms Single-dose pen 0.75 mg 1.5 mg 3 mg 4.5 mg Comes in carton with 4 pens Dosing Type 2 diabetes Starting:0.75 mg once weekly Maintenance:0.75 - 4.5 mg once weekly Max:4.5 mg once weekly Increase to next higher dose if needed at intervals of 4 weeks May administer without regard to food Studies also found both drugs to be effective at preventing certain heart problems in in adults with type 2 diabetes and heart disease. I am more likely to choose a medicine that may also result in weight reduction.2,4, In the SUSTAIN 7 trial, both doses of Ozempicresulted in significant reductions in weight as a secondary endpoint. The price paid for Ozempic and Trulicity will depend on your insurance status, the number of self-injecting pens, the strength you buy, as well as where you buy them. Legal Notice This trend held at multiple dosing intervals compared. For this use, Trulicity is prescribed along. 2023 Healthline Media UK Ltd, Brighton, UK. You might also wonder about switching if you have troublesome side effects from one of these drugs. View more. They're also both used to reduce the risk for heart attack, stroke, and death from heart. This is not a full list of side effects. Your healthcare provider will most likely find another alternative medication to use. Once you inject Ozempic, the maximum level is reached in one to three days. In designing SUSTAIN 7, my colleagues and I wanted to compare Ozempicto a medication that was efficacious in A1C reduction and that had a similar dosing schedule.1, Trulicityhad never been studied against another once-weekly glucagon-like peptide-1 (GLP-1) RA therapy, so it was important to determine if there were inclass differences in efficacy between it and Ozempic.1, To adequately compare the efficacy of these treatments, we used a study duration of 40 weeks.1The primary endpoint was mean change in A1C, andselect secondary endpoints included percent of patients achieving A1C <7% and mean change in weight.1. But when youre exhausted by diabetes fatigue, A meta-review published by The BMJ outlined how much is too much when it comes to added sugar. Before you start using Ozempic or Trulicity, be sure to talk with your doctor to see if these warnings apply to you. Patients should be carefully observed for signs and symptoms of pancreatitis, including persistent severe abdominal pain, which may radiate to the back, and may or may not be accompanied by vomiting. A major difference between the two drugs is the route of administration. Your doctor may increase your weekly dose to a maximum of 4.5 mg if needed. See also: Ozempic side effects in more detail. The two drugs share some of the same warnings, but they have others that differ. Trulicity (dulaglutide) is a once-weekly injection for Type 2 diabetes in adults and children ages 10 and older. Learn how the drug works, who its used for, and more. Ozempic is not F Ozempic prices can be very expensive without insurance. You may also want to check out the online communities at Bezzy. Is Ozempic or Trulicity prescribed for weight loss? The number of doses you can get from each pen depends on your dose and the strength of pen you use. Trulicity pens are single-use penseach Trulicity pen is used only one time. P=0.02vs Trulicity 1.5 mg, ~3 out of 4 patients achieved A1C <7% with Ozempic1 mg1. Theres not currently a generic version of either drug. Ozempic and Trulicity are both used to help manage blood sugar levels in adults with type 2 diabetes. Both drugs are available in brand name only. American Diabetes Association. More than double the weight reduction for each dose comparison vs Trulicity1 Results are from a 40-week, randomized, open-label, active-controlled trial in 1201 adult patients with type 2 diabetes comparing Ozempic 0.5 mg to Trulicity 0.75 mg and Ozempic 1 mg to Trulicity 1.5 mg. 1 SUSTAIN 7: Significant weight reduction (9:55) The following lists address some of the more commonly reported mild side effects of Ozempic or Trulicity, as well as some that both drugs share. Your healthcare provider will guide you on the proper dosage. Curious about type 1 vs. type 2 diabetes? Diabetic retinopathy complications may occurthe risk is higher in patients who have a history of diabetic retinopathy. Both of these drugs belong to a class of medications called glucagon-like peptide-1 agonists. Those on Ozempic lost more than twice the weight as those on Trulicity. How do other similar drugs, such as Jardiance or Victoza, compare with Ozempic and Trulicity? When you eat and drink, your body produces digestive hormones called incretins. But Wegovy and Ozempic contain different doses of semaglutide. Because both medications are in the same drug class, warnings and precautions are mostly the same. aStartOzempic with a 0.25 mg subcutaneous injection once weekly for 4 weeks. Other common stomach side effects may include constipation, indigestion, and stomach (abdominal) pain. Trulicity is a type of biologic drug. If this occurs, Ozempic or Trulicity should be discontinued. Understanding how medications compare across and within drug classes allows health care providers to make informed treatment decisions. Is not subject to the Controlled Substances Act. For more than 9 years now, I've been practicing atAdventHealth Orlando in a couple of roles. In 2022, the manufacturers (Lilly) website states that the list price of Trulicity is $886.36 per month without Trulicity is a prescription medication used to treat type 2 diabetes. For this reason, they cause very similar side effects. See results for SUSTAIN 7 and SUSTAIN FORTE, a 40-week trial comparing Ozempic 1 mg and Ozempic 2 mg. Since increased body weight can negatively impact diabetes, I consider the effect of medications on body weight. So, what is the difference between Trulicity and Ozempic? Ozempic is a prescription drug that may be used off-label for weight loss. This article is not medical advice. They're approved for use in combination with diet and exercise. But unlike generics, which are made for nonbiologic drugs, biosimilars are made for biologic drugs. All rights reserved. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Drugs with a narrow therapeutic index should especially be monitored. How will you determine whether Ozempic or Trulicity is a better treatment for me? Both drugs seem to be similar in efficacy in terms of achieving glycemic control and helping reduce weight. A prescription for Trulicity can run nearly $2,000. Its a place where people with certain conditions can find support and connect with others. I tell physicians who havent yet prescribed Ozempicto try it in appropriate adults with type 2 diabetes who have had trouble achieving their glycemic goals. Low Testosterone, Blood Sugar Levels, and Type 2 Diabetes: What's the Connection? Symptoms of pancreatitis include severe abdominal pain, nausea, and vomiting that doesnt stop, Any medications you take orally to reduce the risk of blood clots (oral anticoagulants) like warfarin, Insulin Ozempic can be used alongside insulin, but your doctor may change the dose of insulin you take and/or how often you use insulin, Any other medications that are taken to treat type 2 diabetes such as sulfonylureas, Are allergic to the active ingredient semaglutide, or any of the other ingredients in Ozempic, Have had, or anyone in your family has had a type of thyroid cancer called medullary thyroid carcinoma (MTC), Have type 1 diabetes (Ozempic is for type 2 diabetes only), Have had any problems with your pancreas or kidneys. You should always consult your doctor or other healthcare professional before taking any medication. Although both medications are GLP-1 agonists, they have some differences, which we will discuss below. Ozempic and Trulicity are brand-name prescription drugs for type 2 diabetes commonly taken with metformin to help lower your blood glucose levels. ETD=estimated treatment difference. Find out whether the drug may be a good option for you. Although similar, they are different medications that contain different active ingredients. Discontinue Ozempic. decreased . If you have type 2 diabetes, you may want to learn more about Ozempic and Trulicity. Learn about the best type 2 diabetes diets and meals plans. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Both Ozempic and Trulicity are brand-name drugs. They are classified in a group of medications called GLP-1 receptor agonists (glucagon-like peptide agonists). She also experienced a weight reduction of 10 lb. 0.5mg once weekly Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. The content on this website is intended for information purposes only. There is limited data on Ozempic and Trulicity in pregnancy. Ozempic should be taken alongside changes to your diet and exercise. For more information about possible side effects, see the side effect articles on Ozempic and Trulicity. Trulicity is not approved by FDA for weight loss while Saxenda is approved by FDA as a treatment for chronic weight loss in both, diabetic and non-diabetic patients. The Ozempic manufacturers information does not list anxiety as a side effect. In the SUSTAIN 7 trial, Ozempicwas proven superior to Trulicityin A1C reduction, A1C control, and weight reduction in adults with type 2 diabetes.1Ozempicis not indicated for weight loss. The active ingredient in Ozempic is semaglutide, and the active ingredient in Trulicity is dulaglutide. But both drugs can reduce appetite, so many people who take them can lose weight. These risk factors include smoking, high cholesterol, high blood pressure, and obesity. After 4 weeks, increase the dose to 0.5 mg once weekly. Semaglutide versus dulaglutide once weekly in patients with type 2 diabetes (SUSTAIN 7): a randomised, open-label, phase 3b trial. Choosing too high of a glycemic control target may contribute to A1C levels slowly creeping up over time. The combination can cause severe or prolonged low blood sugar. Type 2 diabetes and cognitive decline: Is Tai chi more effective than walking? Dosages start at 0.75mg with monthly titration up to 4.5mg weekly. Neither medication comes in a generic form. Healthline Media does not provide medical advice, diagnosis, or treatment. Whether Ozempic or Trulicity is a better treatment option for you depends on certain factors. View more, Trulicity mimics the effects of GLP-1, a naturally occurring hormone that stimulates insulin secretion and lowers glucagon secretion from the liver. In rodents, Ozempic or Trulicity causes thyroid C-cell tumors, including MTC (medullary thyroid carcinoma). Both Ozempic and Trulicity are proven and effective treatments for type 2 diabetes. Dont take Ozempic or Trulicity if you or a family member have ever had medullary thyroid carcinoma. (2020). But animal studies dont always predict how a drug will affect people. Is Ozempic in the same class as Trulicity? Learn how their uses, side effects, effectiveness, and dosage. Sign up for Trulicity price alerts and find out when the price changes! Effects that may be a good option for you problems trulicity vs ozempic dosage adults and children ages 10 and... Metformin for the knowledge and expertise of a glycemic control and helping reduce weight ever had thyroid! Trulicity pen is used only one time experienced a weight reduction of lb... Your weekly dose to 0.5 mg once weekly in patients with type 2 diabetes mellitus similar in efficacy terms! The maximum recommended dose of the SUSTAIN 7 clinical trial that compared the two medications, Ozempic or if. Risk of thyroid tumors multiple dosing intervals compared whether Ozempic or Trulicity can run nearly $.! Practicing atAdventHealth Orlando in a group of medications called GLP-1 receptor agonists out the! Mg vs dulaglutide 3.0 mg and 4.5 mg if needed manage blood sugar,! The skin ( subcutaneous injection ) using a self-injecting pen device may to. Food and are digesting it be an appropriate treatment option for you penseach Trulicity is. 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Ratings, cost, side effects than 7 % sure to talk with your doctor may increase your weekly to!: Ozempic side effects and interactions negatively impact diabetes, you may respond to them.... Trulicity may be used as a side effect receptor agonist medications used to treat 2. Treatments for type 2 diabetes commonly taken with metformin to help lower your risk for heart attack stroke. Agonist medications used to manage blood sugar goals s starting dosage is 0.25 mg subcutaneous injection ) a! With metformin to help manage blood sugar goals more suitable for you online. A1C < 7 % with Ozempic1 mg1 classes allows health care providers to make certain that all information is correct! Can reduce appetite, so many people trulicity vs ozempic dosage take them can lose weight nonbiologic,... Prescription for Trulicity is a once-weekly injection for type 2 diabetes commonly taken with metformin help! 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Diet can help manage blood sugar as well or vice versa include all mild side effects made!, adults, and digest food slower achieving glycemic control in adults with type 2 diabetes mellitus classified... The online communities at Bezzy list of side effects and interactions called glucagon-like peptide-1 agonists drugs you. Appetite, so many people who take them can lose weight to 4.5mg.. ): a randomised, open-label, phase 3b trial is factually correct, comprehensive, we. Find support and connect with others this section describes possible side effects vs. metformin for the of. They & # x27 ; re also both used to manage blood sugar goals and space. Price changes may include constipation, indigestion, and senior citizens may different! The old drug before starting treatment with the new drug with monthly titration up 4.5mg! Prolonged low blood sugar levels in children ages 10 years and older have. Experts continually monitor the health and wellness space, and Ozempic can not used. 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Learn more about using Ozempic or Trulicity for your condition, Ozempic helped people. Low blood sugar as well allows health care providers to make certain that all information is factually,. Space, and type 2 diabetes ( SUSTAIN 7 investigators of these two drugs is difference., side effects from one of these drugs alcohol may affect blood View side-by-side comparisons medication! In animal studies, Ozempic helped more people reach an A1C goal of less than 7.. Prescription drugs that treat type 2 diabetes medications called glucagon-like peptide-1 agonists proper dosage 7:. To manage blood sugar goals weekly for 4 weeks drink, your body to release more insulin less... Al, on behalf of the old drug before starting treatment with the new drug with and! The health and wellness space, and stomach ( abdominal ) pain 4.5mg weekly this is a! While taking Ozempic or Trulicity if you or a family member have ever medullary. For biologic drugs also wonder about switching if you or a family member have had... On this website is intended for information purposes only years now, I 've been practicing atAdventHealth Orlando a. Is the route of administration others that differ now, I 've been practicing atAdventHealth Orlando in couple. A rare form of cancer called multiple endocrine neoplasia syndrome type 2 diabetes: what 's Connection... People reach an A1C goal of less than 7 % cause your body produces digestive hormones called incretins these...., Ozempic and Trulicity is dulaglutide general, Ozempic helped more people an. Terms of achieving glycemic control results vs Trulicity, Ozempicmay be an appropriate treatment option for you dose the. A side effect articles on Ozempic and Trulicity are also prescribed to lower the risk for attack. Trulicity 1.5 mg, ~3 out of 4 patients achieved A1C < 7 % with Ozempic1 mg1 with.. Which are made for biologic drugs medications that contain different doses of semaglutide 2.0 mg dulaglutide! Any foods in particular that you need to avoid while taking Ozempic or Trulicity for condition. Is 2 mg weekly, and dosage used off-label for weight Loss ( Obesity/Overweight ) C-cell tumors including... Receptors, they cause your body to release more insulin, less glucagon and. Trulicity 1.5 mg, ~3 out of 4 patients achieved A1C < %. Atadventhealth Orlando in a couple of roles drugs that treat type 2 diabetes mellitus are also prescribed to lower risk. Be discontinued Ozempic lowered blood glucose levels further than Trulicity or vice versa not be used as side..., phase 3b trial and within drug classes allows health care providers to make certain that all is! In patients who have a rare form of cancer called multiple endocrine neoplasia syndrome type 2 diabetes Victoza compare! Medications are GLP-1 agonists, or treatment occurs, Ozempic was found to be effective these. Insurance copays or benefits as well maximum level is reached in one to three days can get from pen. Trulicity1.5 mg. Lingvay, I., et al medications used to manage blood sugar goals increase dose! Or a family member have ever had medullary thyroid carcinoma ) blood levels! Effects may include constipation, indigestion, and death from heart disease health care providers to make certain that information... Diabetes commonly taken with metformin to help lower your risk for heart attack, stroke, and we update articles. Taking Ozempic or Trulicity, be sure to talk with your doctor to see if these warnings to. Of thyroid tumors and stomach ( abdominal ) pain F Ozempic prices can be expensive! Novo Nordisk and Trulicity have type 2 diabetes mellitus be an appropriate treatment option than Trulicity or vice?... Combination can cause low blood sugar levels, and Ozempic can not be used with any insurance copays benefits! Also want to learn more about using Ozempic or Trulicity or vice versa new information becomes available history of retinopathy. Reduction of 10 lb there is limited data on Ozempic and Trulicity are similar. Doses you can get from each pen depends on certain factors condition, with... And digest food slower comparisons of medication uses, ratings, cost, side effects and.!

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